Our Publications

What is the origin of pancreatic endocrine tumors? Perren A, Michael IP, Marinoni I. In Zen Y “The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery” 4th edition Wiley Press. Sept 2023.

Cancer cells retrace a stepwise differentiation program during malignant progression. Saghafinia S#, Homicsko H, Di Domenico A, Wullscheger S, Perren A, Marinoni I, Ciriello G, Michael IP#*, Hanahan D*. Cancer Discovery 2021 Oct 1;11:2638-57. (#equal contribution, *co-corresponding authors)

A miR-375/YAP Axis Regulates Neuroendocrine Differentiation and Tumorigenesis in Lung Carcinoid Cells. Yang X, Nanayakkara J, Claypool D, Saghafinia S, Wong J, Xu M, Wang X, Nicol C, Michael IP, Hafner M, Yang X, Renwick N. Scientific Reports 2021 May 17;11(1):10455.

A set of microRNAs coordinately control tumorigenesis, invasion, and metastasis. Michael IP, Saghafinia S, Hanahan D. Proc Natl Acad Sci USA 2019 Nov 26;116 (48), 24184-24195.

Synaptic proximity enables NMDAR signaling to promote brain metastasis. Zeng Q, Michael IP, Zhang P, Knott G, Galván J, Zlobec I, Ciriello G, Hanahan D. Nature 2019 Sept 18;573(7775):526–531.

ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis. Michael IP, Saghafinia S, Tichet M, Zangger N, Marinoni I, Perren A, Hanahan D. Dev Cell 2019 May 6;49(3):409-424.e6.

Vessel Normalization by LIGHT induces T cell Infiltration in Primary Brain Cancer and Intratumoural High Endothelial Venules. He B, Jabouille A, Steri V, Johansson-Percival A, Michael IP, Kotamraju VR, Junckerstorff R, Nowak AK, Hamzah J, Lee G, Bergers G, Ganss R. J Pathol 2018 Jun;245(2):209-221.

Angiopoietin-1 deficiency increases tumor metastasis in mice. Michael IP, Orebrand M, Lima M, Volpert O, Quaggin SE, Jeansson M. BMC Cancer 2017 Aug11;17(1):539.

Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation. Allen E, Jabouille A, Rivera LB, Lodewijckx I, Missiaen R, Steri V, Feyen K, Tawney J, Hanahan D, Michael IP, Bergers G. Sci Transl Med 2017 Apr 12;9(385).

Functional malignant cell heterogeneity is maintained by PDGF-DD during pancreatic neuroendocrine tumorigenesis. Cortez E, Gladh H, Braun S, Cordero E, Bocci M, Björkström NK, Miyazaki H, Michael IP, Eriksson U, Folestad E, Pietras K. Proc Natl Acad Sci USA 2016 Feb 16;113(7): E864-73.

Local acting Sticky-trap inhibits VEGF dependent pathological angiogenesis in the eye. Michael IP, Westenskow P, Hacibekiroglu S, Sung HK, Ballios B, Li J, Warren C, Zhang P, Aguilar E, Donaldson L, Marchetti V, Baba T, Hussein S, Iruela-Arispe L, Rini JM, van der Kooy D, Friedlander M, Nagy A. EMBO Mol Med 2014 May6(5):604–623.

MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Han H, Irimia M, Ross PJ, Sung HK, Alipanahi B, David L, Golipour A, Gabut M, Michael IP, Nachman EN, Wang E, Trcka D, Thompson T, O'Hanlon D, Slobodeniuc V, Barbosa-Morais NL, Burge CB, Moffat J, Frey BJ, Nagy A, Ellis J, Wrana JL, Blencowe BJ. Nature 2013 Jun 13;498(7453):241-245.

Simple piggyBac transposon-based mammalian cell expression system for inducible protein production. Li Z*, Michael IP*, Zhou D, Nagy A, Rini JM. Proc Natl Acad Sci USA 2013 Mar 26;110(13):5004-5009.

Adipose Vascular Endothelial Growth Factor Regulates Metabolic Homeostasis Through Angiogenesis. Sung HK, Doh KO, Son JE, Park JG, Bae Y, Choi S, Nelson SML, Cowling R, Nagy K, Michael IP, Koh GY, Adamson SL, Pawson T, Nagy A. Cell Metab 2013 Jan;17(1):61-72.

Highly efficient site-specific transgenesis in cancer cell lines. Michael IP, Monetti C, Chiu AC, Zhang P, Baba T, Nishino K, Agha-Mohammadi S, Woltjen K, Sung HK, Nagy A. Molecular Cancer 2012 Dec;11(1):89.

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Woltjen K, Michael IP, Mohseni P, Desai R, Mileikovsky M, Hämäläinen R, Cowling R, Wang W, Liu P, Gertsenstein M, Kaji K, Sung HK, Nagy A. Nature 2009 Apr 9; 458(7239):766-770.

A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation. Borgoño CA, Michael IP, Komatsu N, Jayakumar A, Kapadia R, Clayman GL, Sotiropoulou G, Diamandis EP. J Biol Chem 2007 Feb 9; 282(6):3640-3652.

Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14. Borgoño CA, Michael IP, Shaw JL, Luo LY, Ghosh MC, Soosaipillai A, Grass L, Katsaros D, Diamandis EP. J Biol Chem 2007 Jan 26; 282(4):2405-2422.

Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins. Obiezu CV, Michael IP, Levesque MA, Diamandis EP. Biol Chem 2006 Jun; 387(6):749-759.

Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression. Michael IP, Pampalakis G, Mikolajczyk SD, Malm J, Sotiropoulou G, Diamandis EP. J Biol Chem 2006 May 5; 281(18):12743-12750.

Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a Novel Serine Protease Potentially Involved in Cancer Progression. Michael IP, Sotiropoulou G, Pampalakis G, Magklara A, Ghosh M, Wasney G, Diamandis EP. J Biol Chem 2005 Apr 15; 280(15):14628-35.

Intron retention: a common splicing event within the human kallikrein gene family. Michael IP, Kurlender L, Memari N, Yousef GM, Du D, Grass L, Stephan C, Jung K, Diamandis EP. Clin Chem 2005 Mar; 51(3):506-15.

Human tissue kallikreins: Physiological roles and applications in cancer. Borgoño CA, Michael IP, Diamandis EP. Mol Cancer Res 2004 May; 2(5):257-80.